Which of the following is a requirement for human subjects research under the Common Rule?

The requirement that research must contribute to generalizable knowledge is a fundamental principle under the Common Rule. This principle ensures that human subjects research aims to expand knowledge that can be applied beyond the immediate study, thus benefiting broader populations and contributing to scientific understanding. When research is designed to produce generalizable findings, it emphasizes the importance of producing results that can inform practice, policy, or future research.

This is central to ethical standards in research, as one of the primary goals is to ensure that studies are not only safe for participants but also valuable in terms of their outcomes. Knowledge that is applicable to wider contexts helps justify the ethical considerations surrounding the use of human subjects, such as the need for informed consent and the ethical treatment of participants.

In this context, the other options do not align with the key principles of the Common Rule. For example, compensation for participants is not universally mandated, nor is peer review required prior to conducting research; these are not conditions outlined in the Common Rule. Only federally funded research does not limit the requirement for consent, as all studies involving human subjects must adhere to consent regulations regardless of funding source.