How often must an IRB conduct continuing review of ongoing research?

The requirement for an Institutional Review Board (IRB) to conduct continuing review of ongoing research is set to ensure that the rights and welfare of research participants are continuously protected throughout the study's duration. Conducting a review at least annually allows the IRB to assess whether the research continues to meet ethical standards, whether any modifications are needed, or if there are unforeseen issues affecting participant safety or well-being.

Regular reviews also provide an opportunity to evaluate the current risks in relation to anticipated benefits, particularly as the research unfolds and more information becomes available. This annual requirement ensures that the research remains in compliance with applicable regulations and ethical guidelines, promoting participant safety and maintaining the integrity of the research process.

Although some studies may have specific circumstances that require more frequent reviews, the minimum requirement remains an annual review, thereby ensuring a systematic oversight mechanism is in place to protect participant interests effectively.