According to the Common Rule, how is research defined?

The definition of research according to the Common Rule is grounded in the understanding that it involves a systematic investigation aimed at developing or contributing to generalizable knowledge. This systematic approach distinguishes research from casual inquiries or non-systematic activities, establishing a framework that allows for the assessment of methodologies, objectives, and outcomes.

By defining research this way, the Common Rule emphasizes the importance of rigor and structure in studies that seek to generate knowledge, especially in fields that involve human subjects. This systematic investigation is crucial because it provides the foundation for ethical considerations and the protections afforded to participants involved in research. Knowledge generated through systematic investigation is expected to be shared and built upon, which is fundamental to the progression of various fields and the protection of human subjects involved in these studies.

This definition underscores the ethical obligation researchers have to conduct their activities with integrity and oversight, ensuring that participants' rights and welfare are prioritized throughout the research process.